Cytoprotective actions of hydrogen sulfide in ischaemia-reperfusion injury
- PMID: 21666033
- DOI: 10.1113/expphysiol.2011.059725
Cytoprotective actions of hydrogen sulfide in ischaemia-reperfusion injury
Abstract
Hydrogen sulfide (H(2)S) has been known as a highly toxic gas for several centuries. There have been considerable advances made in the H(2)S field regarding its physiological role; however, there is much more work that needs to be done. The biosynthesis of H(2)S has been attributed to three endogenous enzymes: cystathionine β-synthase (CBS), cystathionine γ-lyase (CGL or CSE) and 3-mercaptopyruvate sulfurtransferase (3-MST). These enzymes require further investigation to more fully elucidate the cellular expression profile, regulation and precise role of these critical enzymes in the production of H(2)S. In recent years, H(2)S has been demonstrated to have cytoprotective effects in multiple organ systems. In particular, it has been demonstrated that the administration of H(2)S either prior to ischaemia or at reperfusion significantly ameliorates myocardial and hepatic ischaemia-reperfusion injury. Therefore, this review focuses on the cardioprotective and hepatoprotective role of H(2)S. In addition, the review provides a summary of several known molecular targets of H(2)S protection.
Similar articles
-
Ischemia-reperfusion reduces cystathionine-beta-synthase-mediated hydrogen sulfide generation in the kidney.Am J Physiol Renal Physiol. 2009 Jul;297(1):F27-35. doi: 10.1152/ajprenal.00096.2009. Epub 2009 May 13. Am J Physiol Renal Physiol. 2009. PMID: 19439522
-
Hydrogen sulfide: its production, release and functions.Amino Acids. 2011 Jun;41(1):113-21. doi: 10.1007/s00726-010-0510-x. Epub 2010 Feb 27. Amino Acids. 2011. PMID: 20191298 Review.
-
Hydrogen sulfide: its production and functions.Exp Physiol. 2011 Sep;96(9):833-5. doi: 10.1113/expphysiol.2011.057455. Epub 2011 Apr 28. Exp Physiol. 2011. PMID: 21527544
-
Characterisation of cystathionine gamma-lyase/hydrogen sulphide pathway in ischaemia/reperfusion injury of the mouse kidney: an in vivo study.Eur J Pharmacol. 2009 Mar 15;606(1-3):205-9. doi: 10.1016/j.ejphar.2009.01.041. Epub 2009 Feb 5. Eur J Pharmacol. 2009. PMID: 19374832
-
Hydrogen sulfide, the third gaseous signaling molecule with cardiovascular properties, is decreased in hemodialysis patients.J Ren Nutr. 2010 Sep;20(5 Suppl):S11-4. doi: 10.1053/j.jrn.2010.05.004. J Ren Nutr. 2010. PMID: 20797558 Review.
Cited by
-
A mitochondria-targeted chemiluminescent probe for detection of hydrogen sulfide in cancer cells, human serum and in vivo.RSC Chem Biol. 2023 Jul 18;4(9):675-684. doi: 10.1039/d3cb00070b. eCollection 2023 Aug 30. RSC Chem Biol. 2023. PMID: 37654504 Free PMC article.
-
Dose-Dependent Effect of Hydrogen Sulfide in Cyclophosphamide-Induced Hepatotoxicity in Rats.Turk J Gastroenterol. 2023 Jun;34(6):626-634. doi: 10.5152/tjg.2023.22040. Turk J Gastroenterol. 2023. PMID: 37162504 Free PMC article.
-
An Updated Insight Into Molecular Mechanism of Hydrogen Sulfide in Cardiomyopathy and Myocardial Ischemia/Reperfusion Injury Under Diabetes.Front Pharmacol. 2021 Oct 26;12:651884. doi: 10.3389/fphar.2021.651884. eCollection 2021. Front Pharmacol. 2021. PMID: 34764865 Free PMC article. Review.
-
Hydrogen gas post-conditioning attenuates early neuronal pyroptosis in a rat model of subarachnoid hemorrhage through the mitoKATP signaling pathway.Exp Ther Med. 2021 Aug;22(2):836. doi: 10.3892/etm.2021.10268. Epub 2021 Jun 4. Exp Ther Med. 2021. PMID: 34149882 Free PMC article.
-
Hydrogen sulfide donor protects against mechanical ventilation-induced atrophy and contractile dysfunction in the rat diaphragm.Clin Transl Sci. 2021 Nov;14(6):2139-2145. doi: 10.1111/cts.13081. Epub 2021 Jun 16. Clin Transl Sci. 2021. PMID: 34080307 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
