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. 2008 Dec 24;582(30):4191-6.
doi: 10.1016/j.febslet.2008.11.020. Epub 2008 Nov 28.

Testicular aging involves mitochondrial dysfunction as well as an increase in UCP2 levels and proton leak

Sandra Amaral  1 , Paula Mota, Ana Sofia Rodrigues, Luís Martins, Paulo J Oliveira, João Ramalho-Santos
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Testicular aging involves mitochondrial dysfunction as well as an increase in UCP2 levels and proton leak

Sandra Amaral et al. FEBS Lett. .
Free article

Abstract

To address the possibility that mitochondria are involved in the age-related loss of testicular function, we characterized mitochondrial bioenergetics in rat testis. A peak of mitochondrial functionality was detected in adult animals, with a decrease in both young and older animals. In the latter group a decrease in mitochondrial function was matched with an increase in proton leak and expression and activity of uncoupling protein 2 (UCP2), suggesting that proton leak may be involved in managing age-dependent mitochondrial dysfunction.

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