Crystal structure of a continuous three-dimensional DNA lattice
- PMID: 15324813
- DOI: 10.1016/j.chembiol.2004.05.021
Crystal structure of a continuous three-dimensional DNA lattice
Erratum in
- Chem Biol. 2005 Apr;12(4):497
Abstract
DNA has proved to be a versatile material for the rational design and assembly of nanometer scale objects. Here we report the crystal structure of a continuous three-dimensional DNA lattice formed by the self-assembly of a DNA 13-mer. The structure consists of stacked layers of parallel helices with adjacent layers linked through parallel-stranded base pairing. The hexagonal lattice geometry contains solvent channels that appear large enough to allow 3'-linked guest molecules into the crystal. We have successfully used these parallel base pairs to design and produce crystals with greatly enlarged solvent channels. This lattice may have applications as a molecular scaffold for structure determination of guest molecules, as a molecular sieve, or in the assembly of molecular electronics. Predictable non-Watson-Crick base pairs, like those described here, may present a new tool in structural DNA nanotechnology.
Comment in
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"Deoxyribo nanonucleic acid"; antiparallel, parallel, and unparalleled.Chem Biol. 2004 Aug;11(8):1027-9. doi: 10.1016/j.chembiol.2004.08.002. Chem Biol. 2004. PMID: 15324800
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