Clinical significance of elongation factor-1 delta mRNA expression in oesophageal carcinoma - PubMed Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 2004 Jul 19;91(2):282-6.
doi: 10.1038/sj.bjc.6601941.

Clinical significance of elongation factor-1 delta mRNA expression in oesophageal carcinoma

K Ogawa  1 , T Utsunomiya, K Mimori, Y Tanaka, F Tanaka, H Inoue, S Murayama, M Mori
Affiliations
Comparative Study

Clinical significance of elongation factor-1 delta mRNA expression in oesophageal carcinoma

K Ogawa et al. Br J Cancer. .

Abstract

Elongation factor-1 (EF-1) delta is a subunit of EF-1, which is a protein complex that participates in the elongation step of mRNA translation and has recently been considered to correlate with oncogenic transformation. However, there has been no information regarding the clinical significance of EF-1 delta mRNA expression in malignant tumours, including oesophageal carcinoma. Thus, we quantitated the expression of EF-1 delta in malignant and benign oesophageal tissues and associated these levels with clinicopathologic parameters of oesophageal carcinoma. Paired oesophageal tissue samples from cancerous and corresponding noncancerous parts were obtained from 52 patients who underwent curative oesophagectomy. Quantitative analyses of EF-1 delta expression were performed using real-time quantitative reverse transcription-polymerase chain reaction. Elongation factor-1 delta mRNA overexpression in cancerous tissues compared to normal counterparts was observed in 38 of 52 (73%) patients. The mean expression level of EF-1 delta mRNA in cancerous tissues was significantly higher than that in noncancerous tissues (P<0.01). A higher expression of EF-1 delta was significantly correlated with lymph node metastases (P<0.05) and advanced stages (P<0.05). Furthermore, the cause-specific survival of patients with a higher expression of EF-1 delta was significantly poorer than those with a lower expression (5-year cause-specific survival rates; 23 and 54%, respectively, P<0.05). The results of this study indicated that EF-1 delta mRNA expression was significantly higher in cancerous compared to noncancerous oesophageal tissues, and a higher expression of EF-1 delta mRNA was correlated with lymph node metastases, advanced disease stages and poorer prognosis for patients with oesophageal carcinoma.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Elongation factor-1 delta expression in cancerous and noncancerous oesophageal tissues. The horizontal lines indicate the means. Cancer tissues showed significantly higher EF-1 delta mRNA expression levels as compared to noncancerous tissues (P<0.01). The P-value was calculated by the Student's t-test.
Figure 2
Figure 2
Actuarial cause-specific survival in patients with oesophageal carcinoma according to the level of EF-1 mRNA expression.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Anand N, Murthy S, Amann G, Wernick M, Porter LA, Cukier H, Collins C, Gray JW, Demetrick DJ, Lee JM (2002) Gene encoding protein elongation factor EEF1A2 is a putative oncogene in ovarian cancer. Nat Genet 31: 301–305 - PubMed
    1. Bieche I, Olivi M, Champeme MH, Vidaud D, Lidereau R, Vidaud M (1998) Novel approach to quantitative polymerase chain reaction using real-time detection: application to the detection of gene amplification in breast cancer. Int J Cancer 78: 661–666 - PubMed
    1. Bieche I, Onody P, Laurendeau I, Olivi M, Vidaud D, lidereau R, Vidaud M (1999) Real time reverse transcription–PCR assay for future management of ERBB2-based clinical applications. Clin Chem 45: 1148–1156 - PubMed
    1. Buckhaults P, Rago C, St Croix B, Romans KE, Saha S, Zhang L, Vogelstein B, Kinzler KW (2001) Secreted and cell surface genes expressed in benign and malignant colorectal tumors. Cancer Res 61: 6996–7001 - PubMed
    1. Chi K, Jones DV, Frazier ML (1992) Expression of an elongation factor 1 gamma-related sequence in adenocarcinomas of the colon. Gastroenterology 103: 98–102 - PubMed

Publication types

MeSH terms