Matrix metalloproteinases: a review of their structure and role in acute coronary syndrome
- PMID: 14553821
- DOI: 10.1016/s0008-6363(03)00516-9
Matrix metalloproteinases: a review of their structure and role in acute coronary syndrome
Abstract
Objective: To summarize the structure, function, and regulation of matrix metalloproteinases (MMPs) and to review the literature to date on their potential role in the pathogenesis of acute coronary syndromes.
Methods: A recursive strategy starting with a Medline Search for primary articles in the last decade, followed by identification of additional articles of interest among the cited literature in the primary articles, followed by identification of additional articles of interest cited in the secondary articles.
Results: MMPs play a central role in many fundamental processes in human health and disease. In vitro evidence suggests that MMP activity may facilitate atherosclerosis, plaque destabilization, and platelet aggregation. Limited evidence from clinical studies supports a role of MMPs in the development of acute coronary syndromes.
Conclusions: MMP activity likely contributes to the development of acute coronary syndromes and may be an important therapeutic target for future drug development.
Similar articles
-
Matrix metalloproteinases in acute coronary syndromes: current perspectives.Curr Top Med Chem. 2012;12(10):1192-205. doi: 10.2174/1568026611208011192. Curr Top Med Chem. 2012. PMID: 22519449 Review.
-
Next generation matrix metalloproteinase inhibitors - Novel strategies bring new prospects.Biochim Biophys Acta Mol Cell Res. 2017 Nov;1864(11 Pt A):1927-1939. doi: 10.1016/j.bbamcr.2017.06.009. Epub 2017 Jun 19. Biochim Biophys Acta Mol Cell Res. 2017. PMID: 28636874 Review.
-
Matrix metalloproteinases in vascular physiology and disease.Vascular. 2012 Aug;20(4):210-6. doi: 10.1258/vasc.2011.201202. Epub 2012 Aug 15. Vascular. 2012. PMID: 22896663 Review.
-
Matrix metalloproteinases in development and disease.Birth Defects Res C Embryo Today. 2006 Mar;78(1):1-10. doi: 10.1002/bdrc.20065. Birth Defects Res C Embryo Today. 2006. PMID: 16622845 Review.
-
Matrix metalloproteinases in coronary artery disease.Adv Clin Chem. 2014;64:1-72. doi: 10.1016/b978-0-12-800263-6.00001-x. Adv Clin Chem. 2014. PMID: 24938016 Review.
Cited by
-
Immunohistochemical analysis on MMP-2 and MMP-9 for wound age determination.Int J Legal Med. 2015 Sep;129(5):1043-8. doi: 10.1007/s00414-015-1167-5. Epub 2015 Mar 10. Int J Legal Med. 2015. PMID: 25753382
-
Matrix metalloproteinase inhibitors as investigative tools in the pathogenesis and management of vascular disease.Exp Suppl. 2012;103:209-79. doi: 10.1007/978-3-0348-0364-9_7. Exp Suppl. 2012. PMID: 22642194 Free PMC article. Review.
-
Recent findings on the role of gelatinases (matrix metalloproteinase-2 and -9) in osteoarthritis.Adv Orthop. 2012;2012:834208. doi: 10.1155/2012/834208. Epub 2012 Jul 26. Adv Orthop. 2012. PMID: 22900195 Free PMC article.
-
Radiolabelled probes for imaging of atherosclerotic plaques.Am J Nucl Med Mol Imaging. 2012;2(4):432-47. Epub 2012 Oct 15. Am J Nucl Med Mol Imaging. 2012. PMID: 23145360 Free PMC article.
-
Matrix metalloproteinases and their inhibitors in vascular remodeling and vascular disease.Biochem Pharmacol. 2008 Jan 15;75(2):346-59. doi: 10.1016/j.bcp.2007.07.004. Epub 2007 Jul 7. Biochem Pharmacol. 2008. PMID: 17678629 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
