Role of Carbon Monoxide in Vascular Diseases

Title:Role of Carbon Monoxide in Vascular Diseases

Volume: 13 Issue: 6

Author(s): Ignazio Barbagallo, Giuseppina Marrazzo, Alessandro Frigiola, Agata Zappala and Giovanni Li Volti

Affiliation:

Keywords: Carbon monoxide, Heme oxygenase, oxidative stress, hypertension, vascular diseases

Abstract: During the degradation of heme by the enzyme heme oxygenase (HO), Carbon monoxide (CO) is generated. Although it is considered as a non - significant and potentially toxic waste gas of heme catabolism, CO is a key signaling molecule used to regulate different cardiovascular functions. In this review, we focus the protective roles of CO in vascular injury/disease, which may be important to explore the overall protective roles of HO-1/CO system in the pathogenesis of human vascular disease.

Cite this article as:

Barbagallo Ignazio, Marrazzo Giuseppina, Frigiola Alessandro, Zappala Agata and Li Volti Giovanni, Role of Carbon Monoxide in Vascular Diseases, Current Pharmaceutical Biotechnology 2012; 13 (6) . https://dx.doi.org/10.2174/138920112800399086