Human Immunodeficiency Virus Interactions with CD8+ T Lymphocytes | Bentham Science
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Current HIV Research

Editor-in-Chief

ISSN (Print): 1570-162X
ISSN (Online): 1873-4251

Human Immunodeficiency Virus Interactions with CD8+ T Lymphocytes

Author(s): Nitin K. Saksena, Jing Qin Wu, Simon J. Potter, John Wilkinson and Bin Wang

Volume 6, Issue 1, 2008

Page: [1 - 9] Pages: 9

DOI: 10.2174/157016208783572008

Price: $65

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Abstract

Human immunodeficiency virus (HIV)-specific CD8+ T cells can mediate anti-HIV activity by both cytolytic (cytotoxic T lymphocyte or CTL) and non-cytolytic mechanisms (antiviral) and play a crucial role in HIV pathogenesis. Both mechanisms actively contribute to the control of HIV in vivo. The non-cytolytic CD8+T cells from individuals infected with HIV suppress virus replication in CD4+ T cells in vitro by a non-cytolytic mechanism that involves interplay of several chemokines and an unidentified secreted soluble CD8 (+)-cell antiviral factor (CAF). There is immense value of these two distinct CD8 activities in anti-HIV responses and their necessity to be maintained during highly active antiretroviral therapy (HAART). The aim of this review is to provide an overview of some of the novel aspects of CD8+ T cell interactions with HIV, their role in HIV pathogenesis, HAART therapy, HIV disease progression, gene expression and interactions with other cell types during HIV infection.

Keywords: Dendritic Cells, Viremia, CD8 cell antiviral factor, highly active antiretroviral therapy, HIV-1 infection

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