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Review Article

Treating Sensorineural Hearing Loss: Recent Advances in Inner Ear Drug Delivery

Author(s): Dolly N. Vachheta, Yamini Dushyant Shah, Mansi Ninaad Athalye*, Drashty Kumarbhai Kakkad and Mansi Jitenderabhai Darji

Volume 13, Issue 3, 2023

Published on: 22 May, 2023

Page: [167 - 185] Pages: 19

DOI: 10.2174/2210303113666230407082515

Price: $65

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Abstract

This review aims to provide historical, present, and future drug deliveries for treating inner ear disorders. Systemic delivery, such as antibiotics and steroids for the inner ear, was the basis on which current drug delivery systems and devices have been researched and developed. Researchers and clinicians had to develop and deliver drugs locally due to adverse effects caused by drugs systemically. Intratympanic method of antibiotics and steroid delivery has been common; however, newer techniques such as microcatheter implantation, hydrogels, nanoparticles, and intracochlear implants are being investigated successfully. Recently advances in microfluidic and microsystems technology have applied medications directly into the inner ear. This technology will also be adopted to deliver gene therapy, RNA interference technology, and stem cell therapy by clinicians in the future.

Keywords: Sensorineural Hearing Loss (SNHL), Round window membrane (RWM), Oval window (OW), Blood-labyrinth barrier (BLB), intracochlear system, intratympanic system, vestibular and auditory diseases, autoimmune disorders.

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