The Association of LDH Expression and Delayed Cerebral Ischemia in
Patients with Aneurysmal Subarachnoid Hemorrhage: Possible Involvement
of Cerebral Blood Perfusion

Yingwen      Wang; Shuang      Tang; Xiaomin      Yang; Yunchuan      Cao; Xiaoguo      Li; Rui      Xu; Jin      Yan; Zongduo      Guo; Xiaochuan      Sun; Yue      Wu

doi:10.2174/1567202620666221230124832

Abstract

Background and Purpose: Several pieces of evidence suggest that serum lactate hydrogenase (LDH) level is associated with the pathological process of delayed cerebral ischemia (DCI) after aneurysmal subarachnoid hemorrhage (aSAH). This research aimed to investigate the associations of serum LDH level with the occurrence of DCI in aSAH patients.

Methods: A total of 122 patients diagnosed with aSAH within 72h of onset were retrospectively enrolled. The serum levels of LDH between 7:00-8:00 am on day 1, day 3 and day 7, patients’ demographics, and clinical features were collected. Computed tomography perfusion was performed within 7 days after aSAH. The occurrence of DCI was recorded during the hospitalization.

Results: Among all the enrolled patients, 43 (35.2%) developed DCI during hospitalization. Patients occurred DCI were always accompanied by more serious clinical features and found with higher serum LDH levels. LDH levels on day 3 and day 7 after onset were independently associated with the occurrence of DCI and showed high predictive value according to the receiver operating characteristic (ROC) curve. Moreover, there was a strong correlation between LDH and mean cerebral blood flow, transit time, and mean time to peak.

Conclusion: Serum LDH level on day 3 and day 7 may be a valuable, convenient, and rapid predictive indicator for the occurrence of DCI in aSAH patients.

Keywords: Aneurysmal subarachnoid hemorrhage, serum lactate dehydrogenase level, cerebral blood flow, delayed cerebral ischemia, ROC, CTP, EEG.

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DOI https://dx.doi.org/10.2174/1567202620666221230124832	Print ISSN 1567-2026
Publisher Name Bentham Science Publisher	Online ISSN 1875-5739

Current Neurovascular Research

The Association of LDH Expression and Delayed Cerebral Ischemia in Patients with Aneurysmal Subarachnoid Hemorrhage: Possible Involvement of Cerebral Blood Perfusion

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