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Review Article

Discovery and Development of Inflammatory Inhibitors from 2-Phenylchromonone (Flavone) Scaffolds

Author(s): Chen Xu, Meng-Yuan Fang, Ke Wang, Jing Liu, Guang-Ping Tai, Zhao-Ting Zhang* and Ban-Feng Ruan*

Volume 20, Issue 28, 2020

Page: [2578 - 2598] Pages: 21

DOI: 10.2174/1568026620666200924115611

Price: $65

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Abstract

Flavonoids are compounds based on a 2-phenylchromonone scaffold. Flavonoids can be divided into flavonoids, flavonols, dihydroflavones, anthocyanins, chalcones and diflavones according to the oxidation degree of the central tricarbonyl chain, the connection position of B-ring (2-or 3-position), and whether the tricarbonyl chain forms a ring or not. There are a variety of biological activities about flavonoids, such as anti-inflammatory activity, anti-oxidation and anti-tumor activity, and the antiinflammatory activity is apparent. This paper reviews the anti-inflammatory activities and mechanisms of flavonoids and their derivatives reported in China and abroad from 2011 till date (2011-2020), in order to find a good drug scaffold for the study of anti-inflammatory activities.

Keywords: Natural products, Flavonoids, Anti-inflammatory activity, Anti-inflammatory mechanism, 2-phenylchromonone scaffold, Drug.

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