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Review Article

Polypharmacology in the Treatment of Chagas Disease

Author(s): Elena Aguilera, Guzmán Alvarez, Hugo Cerecetto* and Mercedes González *

Volume 26, Issue 23, 2019

Page: [4476 - 4489] Pages: 14

DOI: 10.2174/0929867325666180410101728

Price: $65

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Abstract

The current treatment of Chagas disease is based on monopharmacology where the used drugs have limited efficacy and severe side effects. In order to overcome these limitations, some tools have been described including the development or isolation of new drugs, drug repositioning, and polypharmacology. Here, we review the polypharmacology strategy where compounds belonging to different structural chemotypes were combined in order to affect different biochemical pathways of T. cruzi parasite. Therefore ergosterol biosynthesis inhibitors, anti-inflammatory agents, cardiac dysfunction drugs, trypanothione reductase inhibitors, vitamins, between others, were combined looking for new anti-Chagas treatment. Natural products were also used in the application of this strategy.

Keywords: Chagas disease, polypharmacology, synergism, antagonism, isobologram, cardiac dysfunction drugs.

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