Heart Failure with Preserved Ejection Fraction: Entresto a Possible Option

Title:Heart Failure with Preserved Ejection Fraction: Entresto a Possible Option

Volume: 17 Issue: 2

Author(s): Taylor Bramblett, Mohamed Teleb*, Aymen Albaghdadi, Harsh Agrawal and Debabrata Mukherjee

Affiliation:

• Department of Internal Medicine, Division of Cardiovascular Diseases, Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center, El Paso, TX, 4800 Alberta Ave, El Paso, TX, 79905,United States

Keywords: Heart failure, LCZ696, entresto, preserved ejection fraction, vasodilation, diuresis.

Abstract: Background: Heart failure with preserved ejection fraction (HFpEF) makes up half of diagnosed heart failure (HF) cases and has similar outcomes compared to heart failure with reduced ejection fraction (HFrEF) but a discrepancy in knowledge and approach to treatment. HFpEF is diagnosed using the following criteria: symptoms, preserved ejection fraction (greater than 50%), and evidence of abnormal left ventricular filling or relaxation, or diastolic distensibility or stiffness. Studies conducted to examine the efficacy of angiotensin receptor blockers (ARB) (irbesartan and candesartan), thiazide diuretics (chlorthalidone), and angiotensin converting enzyme inhibitors (ACEI) (perindopril) in the treatment of HFpEF, showed moderate efficacy but no clear benefit. Recently, the FDA has approved a novel drug, which combines an angiotensin receptor neprilysin inhibitor and ARB (valsartan) named LCZ696 (entresto) for possible treatment of HFrEF.

Conclusion: In this article, we will discuss the failure of previous treatment modalities and the promise that LCZ696 (entresto) may hold for treating patients with HFpEF.

Cite this article as:

Bramblett Taylor , Teleb Mohamed *, Albaghdadi Aymen , Agrawal Harsh and Mukherjee Debabrata , Heart Failure with Preserved Ejection Fraction: Entresto a Possible Option, Cardiovascular & Hematological Disorders-Drug Targets 2017; 17 (2) . https://dx.doi.org/10.2174/1871529X17666170703120237