Abstract
Heart failure with preserved ejection fraction (HFPEF) is a syndrome that frequently occurs in older people and patients with cardiovascular risk factors, particularly hypertension. This syndrome is not a specific disease process, whereas is associated with high morbidity and mortality in patients with heart failure with reduced ejection fraction (HFREF) as well. Therefore, a “one size fits all” diagnosis strategy is unlikely to operate for patients with HFPEF. Assessment of left atrial (LA)-left ventricular (LV)-arterial coupling seems to have a clinical impact on hypertensive patients, because HF signs and symptoms have been found to be significantly related to inappropriate LA-LV interaction during diastole and LV-arterial interaction during systole. Two-dimensional speckle tracking echocardiography (2DSTE) is a new tool that may have a role in earlier detecting the impaired LA, LV, and arterial function in asymptomatic patients. This review explored the impact of LA-LV-arterial coupling in understanding the pathophysiology of hypertension as a road to HFPEF, and the possibilities of clinical application by using 2DSTE.
Keywords: Heart failure with preserved ejection fraction, hypertension, left atrial-left ventricular-arterial coupling, twodimensional speckle tracking echocardiography.
Call for Papers in Thematic Issues
Arterial Stiffness in hypertension and left ventricular dysfunction, PWV, Heart Failure
Large artery (aortic) stiffening has important consequences on cardiovascular health, including isolated systolic hypertension, excessive penetration of pulsatile energy into the microvasculature of target organs that operate at low vascular resistance, and abnormal ventricular-arterial interactions that promote left ventricular remodeling, dysfunction and failure. Large artery stiffness independently predicts cardiovascular risk ...read more
Pediatric Hypertension
Scope: This special feature focuses on the latest research and clinical advances in the field of pediatric hypertension. We welcome original research papers, review articles, case reports, as well as technical and methodological discussions from academia and clinical practitioners worldwide. Topics of interest include but are not limited to: Epidemiology ...read more
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