Abstract
The over-prescription and misuse of microbiostatic or microbicidal chemical compounds led to the emergence of antibiotic resistance and multiresistance in bacterial strains. The genetic resistance of bacterial cells is amplified when they are growing in biofilms, known for the high phenotypic resistance or tolerance to antimicrobial agents, explaining their high incidence in the etiology of infectious diseases. Currently, there are many research groups in the entire world focusing their investigations on the elucidation of different aspects of bacterial intra- and intercellular communication dependent on the cellular density and regulated by the quorum-sensing and response system (QS), including the isolation of natural compounds, as well as the synthesis of biomimetic analogues or antagonists of QS molecules, with potential prophylactic and therapeutic value for the management of animal and human infections, as well as for fighting the negative consequences of biofouling phenomenon occurring in natural environments. Taking into account the vital importance of the antifouling protection of the photosyntetic organisms in the natural marine environment, the screening of marine organisms for finding new anti-pathogenic, non-lethal compounds represents a promising perspective for the development of efficient preventive and therapeutic strategies of bacterial infections produced by resistant phenotypes, associated with biofilm development.
Keywords: Biofilms, biofouling, inhibitors, marine organisms, quorum sensing.
Graphical Abstract
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
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Electrochemical C-X bond formation
Conventional methods for carrying out carbon–X bond formation are typically conducted at harsh reaction conditions, and rely on expensive catalysts as well as the use of stoichiometric, and perhaps toxic, oxidants. In this regard, electrochemical synthesis has recently been recognized as a sustainable and scalable strategy for the construction of ...read more
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Organic chemistry, with its intricate dance of molecules and reactions, is undergoing a transformation fuelled by the power of Artificial Intelligence (AI) and Machine Learning (ML). The integration of AI/ML with Organic Chemistry is revolutionizing the field by enhancing the efficiency and accuracy of chemical research and development. These technologies ...read more
N-Heterocyclics: Synthesis, Computational Studies, and Coordination Chemistry - A synthetic perspective
N-heterocycles, such as phenanthroline, quinoline, or their organometallic complexes, are widely used in a variety of fields, including chemistry, biochemistry, and coordination chemistry. They play a key role in many chemical and biological processes as biological ligands, medicinal agents, catalysts in organic synthesis, molecular probes and sensors, as well as ...read more
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