Abstract
Coenzyme Q10 (CoQ10) has been reported as a powerful antioxidant in plasma. Recent in vivo investigations showed that cosmetically applied CoQ10 can reduce photo-aging. However, CoQ10 was barely satisfactory in topical drug delivery because of its poor solubility and high molecular weight. To improve the anti-oxidative efficiency of CoQ10 in skin photo-aging, a novel water-soluble nanoscale solid dispersion of CoQ10 (CoQ10-SD) was prepared by heat melt and high-pressure homogenization method in the present study. Three sizes of CoQ10-SDs were obtained and characterized. The spectral investigations showed that the smaller particle size solution of CoQ10-SD was more effective against ultraviolet (UV) radiation. The UVB radiation absorption and reflection of the CoQ10-SD solution increased with increasing concentration and decreasing particle size. The in vitro antioxidants of CoQ10-SD were also assessed. The results showed that, smaller particle size results in higher antioxidant effect. A lower level of intracellular reactive oxygen species was found when the myocardial cells were treated with CoQ10-SD of smaller size. These ndings indicated that CoQ10-SD can be an effective cosmetic delivery system to protect the skin from early aging induced by UV.
Keywords: Antioxidant study, coenzyme Q10, nanoparticles, solid dispersion, UV protective.
Call for Papers in Thematic Issues
Advanced Inorganic Nanocomposites and their Emerging Applications
This special issue will highlight developments in the recent trends in the synthesis of metal oxides, nanoclusters, biomaterials, 2D nanomaterials, nanocrystals, nanocomposites, etc., and their applications in electrochemical systems, tissue regeneration, energy storage and harvesting, sensors, etc. The novelty of the methods in the chemical synthesis, as well as their ...read more
Advanced Nanotechnology in Forensic Science: Revolutionizing Fingerprint Identification and Crime Scene Analysis
This special issue aims to provide a comprehensive exploration of the innovative fusion between nanotechnology and forensic science. It aspires to bridge the gap between traditional investigative techniques and cutting-edge nanoscale applications, envisioning a paradigm shift in forensic analysis. By compiling the expertise of multidisciplinary experts, the book's objectives include ...read more
Emerging Nanostructures for Sustainable Environment
The pressing challenges of environmental degradation, climate change, and depleting natural resources necessitate innovative and sustainable solutions. Nanostructures, with their unique physicochemical properties, have emerged as powerful tools to address these global concerns. From pollution remediation to renewable energy generation, nanotechnology offers a pathway to a cleaner and more sustainable ...read more
Graphene and 2D Materials for Energy Storage and Conversion.
This thematic issue will discuss the recent advances in graphene-based nanomaterials for different energy technologies. Graphene possesses a high surface area, and stable structure and exhibits many interesting electronic, optical, and mechanical properties due to its 2D crystal structure. Graphene is of both fundamental interest and suitable for a wide ...read more
Related Books
Nanotechnology: A Quick Guide to Materials and Technologies
Recent Advancements in Multidimensional Applications of Nanotechnology
Thin Film Nanomaterials: Synthesis, Properties and Innovative Energy Applications
Advanced Materials and Nano Systems: Theory and Experiment (Part 3)
Nanoelectronic Devices and Applications
Nanoscale Field Effect Transistors: Emerging Applications
Nanoelectronics Devices: Design, Materials, and Applications Part II
Nanoelectronics Devices: Design, Materials, and Applications (Part I)
Role of Nanotechnology in Cancer Therapy
Synthesis and Applications of Semiconductor Nanostructures
14
