Abstract
Preeclampsia is now recognized as a risk factor for developing cardiovascular and renal disease in the mother later in life. Recently, certain substances have been identified, that are be either over- or under-expressed in patients with preeclampsia. One of these biomarkers that is over-expressed in the maternal blood is a soluble VEGF receptor, sFlt1. During the first third trimester of that pregnancies which will evolve in preeclampsia, sFtl1 is higher compared to normal; this increase correlates positively with the severity of the disease and decreases significantly after the birth.
It has also been demonstrated that a soluble form of endoglin is produced and released into the maternal circulation in women with preeclampsia. This substance is capable of inhibiting the endothelial effects of TGF β 1. It is consistently elevated in women that will develop preeclampsia.
Recently two other early markers have been studied: neutrophil gelatinase-associated lipocalin (NGAL) and pregnancyassociated plasma protein A (PAPP-A). The serum concentrations of NGAL appear to be higher in preeclampsia as compared to normal pregnancies and significant differences are seen in each trimester. Decreased levels of PAPP-A in the first trimester appear to be a sensitive marker for early onset preeclampsia in which placental damage occurs. In this review we try to give a look to this pathology and to the biomarkers that might be involved.
Keywords: Ngal, preeclampsia, PAPPA-A, m-RNA, cardiovascular and renal disease, RISK FACTORS IN PREMATURE INFANTS, serum concentrations, pregnancies
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RARE CASES IN GYNECOLOGY-OBSTETRICS
With the development of diagnostic and therapeutic techniques (such as ART techniques) and the immersion of new pathologies (such as COVID19), we are witnessing an increase in the incidence of pathologies that were previously described as rare or exceptional. the practitioner sometimes confronts difficult situations in these cases in diagnostic ...read more
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