Mitochondria are key determinants of cellular health. However, the functional role of
mitochondria varies from cell to cell depending on the relative demands for energy …

Cardiac hypertrophy is often initiated as an adaptive response to haemodynamic stress or
myocardial injury, and allows the heart to meet an increased demand for oxygen. Although …

Non-alcoholic fatty liver is the most common liver disease worldwide. Here, we show that the
mitochondrial protein mitofusin 2 (Mfn2) protects against liver disease. Reduced Mfn2 …

Mitochondrial architecture is involved in several functions crucial for cell viability,
proliferation, senescence, and signaling. In particular, mitochondrial dynamics, through the …

Mitochondria form a highly interconnected tubular network throughout the cell via a dynamic
process, with mitochondrial segments fusing and breaking apart continuously. Strong …

Mitochondrial dysfunction has been implicated in the development of insulin resistance (IR);
however, a large variety of association and intervention studies as well as genetic …

Skeletal muscle possesses dramatic metabolic plasticity that allows for the rapid adaptation
in cellular energy transduction to meet the demands of the organism. Obesity elicits changes …

Mitochondria are involved in ATP supply to cells through oxidative phosphorylation
(OXPHOS), synthesis of key molecules and response to oxidative stress, as well as in …

Aging is associated with a decline in mitochondrial function and the accumulation of
abnormal mitochondria. However, the precise mechanisms by which aging promotes these …

AMP-activated protein kinase (AMPK) is a metabolic fuel gauge conserved along the
evolutionary scale in eukaryotes that senses changes in the intracellular AMP/ATP ratio …