Cardiotoxicity of Targeted Therapies in Children with Haematological Malignancies and Solid Tumors | Bentham Science
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Anti-Cancer Agents in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1871-5206
ISSN (Online): 1875-5992

Mini-Review Article

Cardiotoxicity of Targeted Therapies in Children with Haematological Malignancies and Solid Tumors

Author(s): Athanasios Bangeas and Athanasios Tragiannidis*

Volume 23, Issue 15, 2023

Published on: 09 June, 2023

Page: [1702 - 1709] Pages: 8

DOI: 10.2174/1871520623666230525162147

Price: $65

Open Access Journals Promotions 2
Abstract

Cardiotoxicity represents an important acute or chronic adverse event of treatment modalities for childhood cancer. In the last two decades the emergence of novel cancer therapies has aimed to increase unaided or mostly in combination with conventional chemotherapy for the survival rates of pediatric cancer especially for those patients with relapsed and/or refractory disease. The use of emerging targeted therapies in combination with conventional chemotherapy is related to cardiovascular adverse events mostly reported in adults. The aim of our short review was to investigate the cardiotoxic side effects of targeted chemotherapeutic agents as monoclonal antibodies and small molecules in pediatric cancer patients.

Keywords: Cardiotoxicity, children, cancer, monoclonal antibodies, small molecules, pediatric cancer.

Graphical Abstract
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