Therapeutic Implications of Superoxide Dismutase And Its Importance in Kinase Drug Discovery

Title:Therapeutic Implications of Superoxide Dismutase And Its Importance in Kinase Drug Discovery

Volume: 17 Issue: 22

Author(s): Nameet Kaur, Arun K. Sharma, Adeeba Shakeel, Vipin Kumar, Aarti Singh, Apoorv Gupta, Deepa Suhag, Satyendra K. Rajput*Monalisa Mukherjee*

Affiliation:

• Pharmacology and Toxicology, Amity Institute of Pharmacy, Amity University-Uttar Pardesh, Sector- 125, Noida, Uttar Pradesh,India

• Amity Institute of Click Chemistry, Molecular Science and Engineering laboratory, Amity University, NOIDA, Uttar Pradesh, Sector-125, Noida, Uttar Pradesh,India

Keywords: Superoxide dismutase, kinase, oxidative stress, click chemistry, gene modulation, nano-formulation.

Abstract: In recent years, several scientific investigations have reported the therapeutic implications of superoxide dismutase (SOD) against oxidative stress and -induced pathology in clinical and preclinical trials. Indeed, various kinase, molecular signaling and physiological process has altered by reactive oxygen species. In spite of the abundant available literature reports, patents, clinical trials and commercialized products, the therapeutic application of SOD as a potential drug still remains unclear. Owing to the technical challenges associated with the utilization of SOD as a drug, we revisited the structural arrangement and cellular signaling, significant association with kinase, exploring the new target sites and introducing new formulation strategies such as gene modulation, nano-formulations and click chemistry is a prerequisite. In-addition to gene modulation strategies, encapsulated formulation within a nano-carrier for producing promising SOD therapeutic effects, application of click chemistry including bioconjugation and cyclo-addition are the most prominent methods to produce highly efficient SOD formulations. Thus, the present review enlightens the foremost technique which may have better interaction with kinase and other cellular signaling for regulating the physiological process.

Cite this article as:

Kaur Nameet , Sharma K. Arun, Shakeel Adeeba , Kumar Vipin , Singh Aarti , Gupta Apoorv, Suhag Deepa , Rajput K. Satyendra *, Mukherjee Monalisa *, Therapeutic Implications of Superoxide Dismutase And Its Importance in Kinase Drug Discovery, Current Topics in Medicinal Chemistry 2017; 17 (22) . https://dx.doi.org/10.2174/1568026617666170307112837